Adapalene Explained

Differin

Adapalene is a strongly recommended acne retinoid that also helps post-acne marks; it is a medicine, so use it as a doctor directs, wear sunscreen by day, and skip it in pregnancy.

Pregnancy: avoidEvidence: strong

Label names (INCI): Adapalene

Written by the Oliareen editorial teamDermatologist review: pendingHow we write

What it does

A retinoid that unclogs pores, calms acne inflammation and helps fade post-acne marks; stays stable next to benzoyl peroxide.

Often discussed for

This doesn't mean everyone with these needs it.

Concerns

Skin types

How to approach it

If you're new to it

Start one new product at a time and patch test first: a little on the side of the jaw for a few days. Keep the rest of the routine simple.

General education, not a diagnosis or treatment plan.

Works well with

Examples of common pairings, not guaranteed combinations.

Use carefully with

Stacking several actives raises the risk of irritation. If you're on any prescribed medicine, ask your doctor before adding an active.

AHA (in the same session)
BHA (salicylic acid) (in the same session)
Retinoids
Avoid in pregnancy and when planning pregnancy (EMA contraindication, precautionary)
Irritation/peeling possible in the first 2-6 weeks; follow the product's or doctor's directions
Use at night; daily SPF
A pharmacy medicine in many countries; ask a pharmacist or doctor

Possible reactions

Stop if burning doesn't settle, or if you get a red rash, itching, swelling or peeling. Swelling of the face, lips or eyes, or trouble breathing, needs urgent medical care.

When to see a doctor

Evidence and timing

Evidence: Evidence: strong
Time to see a change (weeks): 8-12

Evidence comes from studies of specific formulas and strengths. Your product may behave differently.