Cysteamine Explained

Cysteamine is a wash-off cream that faded melasma better than placebo in trials; results take about 4 months.

Evidence: moderate

Label names (INCI): Cysteamine HCl, Cysteamine Hydrochloride

Written by the Oliareen editorial teamDermatologist review: pendingHow we write

What it does

Short-contact (wash-off) cream that reduces pigment in melasma.

Often discussed for

This doesn't mean everyone with these needs it.

Concerns

Skin types

How to approach it

If you're new to it

Start one new product at a time and patch test first: a little on the side of the jaw for a few days. Keep the rest of the routine simple.

General education, not a diagnosis or treatment plan.

Works well with

Examples of common pairings, not guaranteed combinations.

Sunscreen

Use carefully with

Stacking several actives raises the risk of irritation. If you're on any prescribed medicine, ask your doctor before adding an active.

Strong smell and short-lived stinging
Wash off after the set time

Possible reactions

Stop if burning doesn't settle, or if you get a red rash, itching, swelling or peeling. Swelling of the face, lips or eyes, or trouble breathing, needs urgent medical care.

When to see a doctor

Evidence and timing

Evidence: Evidence: moderate
Time to see a change (weeks): 12

Evidence comes from studies of specific formulas and strengths. Your product may behave differently.