EGF Explained
Epidermal growth factor · Growth factors · bFGF · IGF-1
EGF is a growth-factor protein used after skin procedures to support repair; evidence for everyday anti-aging use is limited.
Pregnancy: avoidEvidence: limited
Label names (INCI): sh-Oligopeptide-1, rh-Oligopeptide-1, sh-Polypeptide-1, sh-Oligopeptide-2
Written by the Oliareen editorial teamDermatologist review: pendingHow we write
What it does
Proteins that tell skin cells to multiply and migrate during wound repair; penetration of intact skin is doubtful.
Often discussed for
This doesn't mean everyone with these needs it.
Concerns
- Fine lines
- Dullness
- Redness
How to approach it
If you're new to it
Start one new product at a time and patch test first: a little on the side of the jaw for a few days. Keep the rest of the routine simple.
General education, not a diagnosis or treatment plan.
Works well with
Examples of common pairings, not guaranteed combinations.
Use carefully with
Stacking several actives raises the risk of irritation. If you're on any prescribed medicine, ask your doctor before adding an active.
- AHA
- BHA (salicylic acid)
- Pure vitamin C (L-ascorbic acid)
- Avoid on undiagnosed lesions or skin cancers
- Pregnancy: no data, avoid as precaution
- Unstable with acids/extreme pH
Possible reactions
Stop if burning doesn't settle, or if you get a red rash, itching, swelling or peeling. Swelling of the face, lips or eyes, or trouble breathing, needs urgent medical care.
When to see a doctorEvidence and timing
- Evidence
- Evidence: limited
- Time to see a change (weeks)
- 4-12
Evidence comes from studies of specific formulas and strengths. Your product may behave differently.
Read next
Sources
- Kim HK et al. J Cosmet Dermatol 2015 (rhEGF cream, 29 pts, 8 wk open-label)
- Schouest JM et al. J Drugs Dermatol 2012 (EGF serum, 29 pts)
- Medicina Clinica (Engl) 2016 rhEGF commentary